Our partners AstraZeneca have today announced the high-level results from the primary analysis of their Phase III trial of the ChAdOx1 nCoV-19 coronavirus vaccine in the US. They confirm that the vaccine efficacy is consistent with the interim analysis results announced on Monday 22 March 2021.
- Primary analysis, part of pre-specified trial protocol, follows interim analysis on Monday 22 March
- Data are consistent with interim analysis, and will form submission by AstraZeneca to US FDA
- Vaccine 76% effective against symptomatic COVID-19, and 100% effective against severe or critical disease and hospitalisation
This primary efficacy analysis included the accrual of 190 symptomatic cases of COVID-19 from the 32,449 trial participants, an additional 49 cases to the previously announced interim analysis.
In addition, results were comparable across age groups, with vaccine efficacy of 85% in adults 65 years and older. A key secondary endpoint, preventing severe or critical disease and hospitalisation, demonstrated 100% efficacy.